ISSN 2398-2969      

Liver: biopsy

Clapis
Contributor(s):

William Lewis

Vladimir Jekl


Introduction

  • Liver biopsies can be extremely useful in managing rabbits with liver disease Liver: disease.
  • Liver biopsies are almost certainly under-utilized in clinical practice.

Uses

  • Confirming a diagnosis and offering the appropriate treatment and prognosis to owners can prove invaluable. This may be instigated by raised liver enzymes, a palpably large liver or radiographic or ultrasound changes.
  • Other modalities such as CT Computed tomography and MRI Magnetic resonance imaging may also provide incentive to perform liver biopsies.

Advantages

  • If a definitive disease process can be identified, then a specific treatment protocol can be recommended. This may involve antibiotics, liver support or chemotherapy protocols.
  • Having a definite diagnosis also provides a prognosis which is useful for both clinicians and owners.

Disadvantages

  • The disadvantages can be the risk of anesthesia Anesthesia: general, risk of hemorrhage post-biopsy and financial implications for the owner.

Requirements

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Preparation

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Procedure

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Aftercare

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Outcomes

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Prognosis

  • Generally an uneventful recovery from the procedure depending on the physical status of the patient at the time of surgery.
  • Long-term prognosis depends on the diagnosis and would be grave for certain tumors, eg lymphoma.

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Daggett A, Loeber S, Le Roux A B et al (2021) Computed tomography with Hounsfield unit assessment is useful in the diagnosis of liver lobe torsion in pet rabbits (Oryctolagus cuniculus). Vet Radiol Ultrasound 62 (2), 210-217 PubMed.
  • Stock E, Vanderperren K, Moeremans I et al (2019) Use of contrast-enhanced ultrasonography in the diagnosis of a liver lobe torsion in a rabbit (Oryctolagus cuniculus). Vet Radiol Ultrasound PubMed.
  • Proença L M, Camus M, Nemeth M et al (2015) Diagnostic quality of percutaneous fine-needle aspirates and laparoscopic biopsy specimens of the liver in rabbits (Oryctolagus cuniculus). JAVMA 246 (3), 313-320 PubMed.
  • Mentré V, Bulliot C, Linsart A et al (2014) Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus). Vet Rec 174 (26), 658 PubMed.
  • Siller-Matula J M, Plasenzotti R, Spiel A et al (2008) Interspecies differences in coagulation profile. Thromb Haemost 100 (3), 397-404 PubMed.

Other sources of information

  • Saunders R (2013) Liver Biopsy and Lobectomy. In: BSAVA Manual of Rabbit Surgery, Dentistry and Imaging. Eds: Harcourt-Brown F & Chitty J. BSAVA, UK. pp 169-171.

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