ISSN 2398-2969      

Serum fructosamine

Clapis

Overview

  • Glycosylated protein complexes.
  • Forms in blood in a non-enzymic, non-insulin-dependent manner.
  • [Fructosamine] proportional to [glucose]   Blood biochemistry: glucose   over life-span of protein - mostly albumin (1-2 weeks).
  • Used to identify long-term presence of hyperglycemia.
  • Less affected by short-term factors: stress, feeding, exercise.
  • Useful in prey animals where handling alone can give falsely elevated blood glucose measurements.

Sampling

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Tests

Methodologies

  • Photometric (colorimetric) method based on the ability of ketoamines to reduce nitroblue tetrazolium (NBT) to formazan in an alkaline medium.

Availability

  • Available in most commercial laboratories.

Validity

Sensitivity

  • Good sensitivity for glycosylated proteins.

Specificity

  • Color may be generated by compounds other than glycosylated proteins, eg elevated bilirubin values. This may result in falsely elevated values. Second generation assays, if used, are highly specific for glycosylated proteins.

Predictive value

  • A diagnosis of diabetes mellitus should not be based entirely on fructosamine values.
  • Clinical signs, repeat urinalysis and blood glucose   Blood biochemistry: glucose  values should also be taken into consideration.

Result Data

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Conaway H H, Faas F H, Smith S D & Saunders L L (1981) Spontaneous diabetes mellitus in the New Zealand white rabbit: physiological characteristics. Metabolism 30 (1), 50-56 PubMed.

Other sources of information

  • Harpole T, Runyeard V, English K & Archer J (2002) Serum Fructosamine in Hyperglycaemic Rabbits. In: 2th ECVIM-CA/ESVIM Congress.
  • Holloway H K R & Carmichael N G (2001) Significance of Serum Fructosamine in Rabbits. In: BSAVA Congress, Birmingham, UK.

Organisation(s)

  • Idexx Laboratories, PO Box 4, Wetherby, West Yorkshire LS22 4ZR, UK.
  • Pinmoore Animal Laboratory Services, The Coach House, Town House Barn, Tarporley Road, Clotton, Tarporley, Cheshire CW6 0EG, UK.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code