ISSN 2398-2969      

Blood biochemistry: gammaglutamyl transferase

Clapis

Synonym(s): GGT, Gammaglutamyl transpeptidase


Overview

  • Gammaglutamyl transferase (GGT) is a membrane-associated enzyme.
  • In the rabbit GGT is found in the liver and in the kidney
  • Liver GGT is found primarily in the epithelium of the bile ducts.
  • The hepatobiliary system is therefore the primary source of serum GGT and is more diagnostic for hepatobiliary disease than for hepatocellular damage.
  • In the rabbit, GGT is also located in renal epithelium and in cases of renal damage, urine GGT may be increased in addition to plasma concentrations.

Sampling

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Tests

Methodologies

  • Varies between laboratories, usually colorimetric method based on enzymatic reaction.

Availability

  • Widely available.

Technique (intrinsic) limitations

  • Test results most significant in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Mancinelli E, Shaw D J & Meredith A L (2012) ³-Glutamyl-transferase (GGT) activity in the urine of clinically healthy domestic rabbits ( Oryctolagus cuniculus)Vet Rec 171 (19), 475 PubMed.

Other sources of information

  • Varga M (2014) Clinical Pathology. In: Textbook of Rabbit Medicine. 2nd edn. Butterwoth Heinemann Elsevier, UK. pp 111-136.
  • Weswche P (2014) Clinical Pathology. In: BSAVA Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA, UK. pp 124-137.
  • Phelps C A & Mayer J (2013) Gammaglutamyl Transferase. In: Clinical Veterinary Advisor Birds and Exotic Pets. Eds: Mayer J & Donnelly T M. Eslevier, USA. pp 617-618.

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