ISSN 2398-2969      

Blood biochemistry: creatine phosphokinase

Clapis

Synonym(s): CPK, CK, Creatinine kinase


Overview

  • Occurs as 3 isoenzymes in skeletal muscle, cardiac muscle and central nervous system (CNS):
    • CK1 (BB) in brain, peripheral nerve, cerebrospinal fluid and viscera. Not found in serum.
    • CK2 (MB) in cardiac muscle, with very small amounts in skeletal muscle.
    • CK3 (MM) in skeletal and cardiac muscle.
  • Most sensitive indicator of muscle damage.
  • Half-life 2-4 h.
  • Levels peak 6-12 h post-injury, returning to normal in 2-3 days after cessation of injury.
  • Persistent elevation indicates continuing or active disease.

Sampling

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Tests

Methodologies

  • Methods (and reference interval) vary between laboratories.
  • Enzymatic/spectrophotometric measurement.

Availability

  • Widely available at commercial laboratories.

Result Data

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Jenkins J R (2008) Rabbit diagnostic testing. J Exot Pet Med 17 (1), 4-15 VetMedResource.
  • Melillo A (2007) Rabbit clinical pathology. J Exot Pet Med 16 (3), 135-145 JExotPetMed.

Other sources of information

  • Wesche P (2014) Clinical Pathology. In: Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA. pp 124-137.
  • Saunders R & Rees Davies R (2005) Common Laboratory Abnormalities. In: Notes on Rabbit Internal Medicine. Blackwell Publishing, UK. pp 69-88.

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!