ISSN 2398-2969      

Blood biochemistry: bicarbonate

Clapis

Synonym(s): HCO3


Overview

  • The renal regulation of acid-base balance in rabbits is different in comparison to other species.
  • Rabbits have a limited ability to transfer hydrogen or bicarbonate ions between blood and urine.
  • Some metabolic pathways that are present in other species are absent or restricted.
  • Rabbits therefore have a reduced ability to cope with distubances to acid: base balance.
  • A large bicarbonate load can reach the kidney of rabbits as a result of bacterial fermentation in the gut and from tissue metabolism of acetate.
  • In other species, bicarbonate is neutralized by the products of ureagenesis and alkalosis is avoided, however in rabbits, insufficient ammonium may be available from tissue metabolism to neutralize bicarbonate.

Sampling

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Tests

Methodologies

  • Measures total carbon dioxide released when sample mixed with a strong acid.

Availability

  • Widely available in commercial laboratories.

Technique (intrinsic) limitations

  • Test results only significant in conjunction with other laboratory results in clinical findings.

Result Data

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Varga M (2014) Ed. Rabbit Basic Science. In: Textbook of Rabbit Medicine. 2nd edn. Elsevier, UK. pp 3-110.
  • Wesche P (2014) Clinical Pathology. In: Manaual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA. pp 124-137.
  • Saunders R A & Reese Davies R (2005) Common Laboratory Abnormalities. In: Notes of Rabbi int Me. Blackwell Publishing, UK. pp 69-88

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