ISSN 2398-2969      

Vitamin D

Clapis

Synonym(s): Vitamin D3, Cholecalciferol, Vitamin D2, Ergocalciferol, Calciferol, Calcidiol, 25-hydroxy-cholecalciferol, Calcitriol, 1,25-dihydroxycholecalciferol


Introduction

Name

  • Vitamin D.

Class of drug

  • Vitamin.

Description

Chemical name

  • Calciferol.

Molecular formula

  • C27H44O3.

Molecular weight

  • 416.636.

Physical properties

  • Colorless, crystalline solid.
  • White crystalline powder.

Storage requirements

  • Calcitriol capsules: protect from moisture, heat, and light; store in tight, light-resistant containers at 15-30ºC.
  • Calcitriol oral solution: protect from light; store at 15-30ºC.
  • Calcitriol injection: store at room temperature (25ºC); freezing should be avoided (brief exposure to temperatures up to 40ºC does not adversely affect the injection); exposure to excessive heat should be avoided.

Uses

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Indications

  • In other species, used to control hypocalcemia associated with chronic renal failure (using alfacalcidol and calcitriol), immune-mediated hypoparathyroidism or following thyroidectomy.
  • Management of vitamin D deficiency associated with intestinal malabsorption or chronic liver disease in other species.
  • Management of renal secondary hyperparathyroidism by reducing serum parathyroid concentrations.

Administration

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Pharmacokinetics

Precautions

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Interactions

With other drugs

  • Sucralfate decreases the absorption of vitamin D.
  • Magnesium or calcium-containing antacids may cause hypermagnesemia or hypercalcemia Hypercalcemia when used with vitamin D.
  • Hypercalcemia may develop if used in combination with thiazide diuretics.
  • Hypercalcemia may potentiate the toxic effects of verapamil Verapamil or digoxin Digoxin, and close monitoring is advised.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Emerson J A, Whittington J K, Allender M C et al (2014) Effects of ultraviolet radiation produced from artificial lights on serum 25-hydroxyvitamin D concentration in captive domestic rabbits (Oryctolagus cuniculi). Am J Vet Res 75 (4), 380-384 PubMed.
  • Jekl V & Redrobe S (2013) Rabbit dental disease and calcium metabolism–the science behind divided opinions. JSAP 54 (9), 481-490 PubMed.

Other sources of information

  • Meredith A (2015) BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Gloucester. pp 20-21.
  • Prebble J (2014) Nutrition and Feeding. In: Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA, Gloucester, 27-35.
  • Varga M (2014) Rabbit Basic Science. In: Textbook of Rabbit Medicine.  2nd edn.  Butterworth Heinemann Elsevier, Edinburgh. pp 3-108.
  • McEvoy G K (2005) Ed American Hospital Formulary Service- Drug Information 2005. Ed: Bethesda M D. American Society of Health-System Pharmacists, Inc. (Plus Supplements). pp 3545.

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