ISSN 2398-2969      

Prochlorperazine

Clapis
Contributor(s):

Vicki Baldrey

Vetstream Ltd


Introduction

Name

  • Prochlorperazine.

Class of drug

  • Piperazine phenothiazine.
  • CNS dopamine receptor blocker.

Description

Chemical name

  • 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine.

Molecular formula

  • C20H24CIN3S.

Molecular weight

  • 373.943g/mol

Physical properties

  • Viscous liquid, freely soluble in water and alcohol.

Storage requirements

  • Store out of direct sunlight.

Uses

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Indications

  • It is used predominantly to control nausea associated with vestibular disease.

Administration

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Precautions

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Interactions

With other drugs

  • CNS depressant agents, eg anesthetics, narcotic analgesics.
    • May cause additive CNS depression.
  • Quinidine
    • Given with phenothiazines may cause additive cardiac depression.
  • Antacids or antidiarrheal preparations, eg bismuth subsalicylate or kaolin/pectin mixtures.
    • May reduce gastrointestinal absorption of oral phenothiazines.
  • Propranolol 
    • Increased blood levels of both drugs may result if propanolol is administered with phenothiazines.
  • Epinephrine Epinephrine.
    • Phenothiazines block alpha-adrenergic receptors which, may lead to unopposed beta activity causing vasodilation and increased cardiac rate.
  • Phenytoin
    • Metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) BSAVA small animal formulary, Part B: Exotics. 9th edn. John Wiley & Sons, Gloucester.
  • Keeble E (2014) Nervous system and musculoskeletal disorders. In: BSAVA Manual of rabbit medicine. Eds: Meredith A & Lord B pp 214-231.
  • Varga M (2014) Therapeutics. In: Textbook of rabbit medicine. 2nd edn. Butterworth-Heinemann, Oxford pp 137-177.

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