ISSN 2398-2969      

Benzylpenicillin

Clapis
Contributor(s):

Anna Meredith

Synonym(s): Penicillin G, Penicillin G potassium, Benzylpenicillin potassium salt, Penicillin G sodium, Benzylpenicillin sodium salt


Introduction

Name

  • Penicillin G.

Class of drug

  • Penicillin antibiotic.

Description

Chemical name

  • Sodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate.
  • Potassium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate.

Molecular formula

  • Benzylpenicillin sodium: C16H17N2NaO4S.
  • Benzylpenicillin potassium: C16H17KN2O4S.

Molecular weight

  • Benzylpenicillin sodium: 356.37.
  • Benzylpenicillin potassium: 372.48.

Physical properties

  • Benzylpenicillin sodium: white/yellow crystalline powder with a slight odor.
  • Benzylpenicillin potassium: liquid.​

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Probenecid
  • Blocks the renal tubular excretion of penicillins, producing higher and more prolonged plasma concentrations.
Aminoglycosides (eg gentamicin)
  • May inactivate penicillins when mixed together in parenteral solutions Gentamicin.
Streptomycin
  • Synergistic action. However, as their pharmacokinetics differ, the use of such compound preparations is generally thought to be unjustified Streptomycin.

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Jekl V, Hauptman K, Minarikova A et al (2016) Pharmacokinmetic study of benzylpenicillin potassium after intramuscular administration in rabbits. Vet Rec 179 (1), 18 PubMed.
  • Ivey E & Morrisey J (2000) Therapeutics for rabbits. Vet Clin North Am Exotic Anim Pract 3 (1), 183-216 PubMed.

 

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