ISSN 2398-2969      

Benazepril

Clapis

Synonym(s): Banacep, Benazacare, Bexepril, Fortekor, Nelio, Prilben


Introduction

Name

  • Benazepril hydrochloride.

Class of drug

  • Angiotensin converting enzyme (ACE) inhibitor.

Description

Chemical name

  • [S-(R1-R)]-3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine-1-acetic acid.

Molecular formula

  • C24H28N2O5.

Molecular weight

  • 424.49.

Storage requirements

  • Store in a dry place.

Uses

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Indications

  • Treatment of congestive heart failure   Heart: congestive heart failure  .
  • Treatment of hypertension.
  • Beneficial cardiac effects have been confirmed in experimental models using rabbits.
  • May be of benefit in the treatment of chronic renal insufficiency although the use of ACE inhibitors for renal failure   Kidney: renal failure  in rabbits has not been fully validated.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Can be administered in combination with diuretics and the inodilator, pimobendan   Pimobendan  .
  • Combination drug therapy using benazepril, furosemide   Furosemide  and pimobendan   Pimobendan  may have hypotensive effects.  
  • Anesthetics and sedative drugs may exacerbate hypotensive effects.
  • Use with potassium-sparing diuretics, eg spironolactone, may cause hyperkalemia   Hyperkalemia  .
  • Use with NSAIDs   Therapeutics: non-steroidal anti-inflammatory drugs  may increase risk of nephrotoxicity.

Monitoring

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Xio P, Gao C, Fan J et al (2011) Blockade of angiotensin II improves hyperthyroid induced abnormal atrial electrophysiological properties. Regul Pept 169 (1-3), 31-38 PubMed.
  • Reusch B (2005) Investigation and management of cardiovascular disease in rabbits. In Pract 27 (8), 418-425 VetMedResource.
  • Li D Y, Zhao K, Zhou J F et al (2004) Changes of expressions of VEGF, bFGF and angiogenesis, and effect of benazepril, bFGF on angiogenesis in acute myocardial infarction models of the rabbits. Biomed Environ Sci 17 (4), 442-451 PubMed.

Other sources of information

  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Saunders R (2014) Therapeutics. In:BSAVA Manual of Rabbit Medicine. Eds: Meredith A & Lord B. BSAVA, Gloucester.
  • Varga M (2014) Textbook of Rabbit Medicine. 2nd edn. Butterworth Heinemann Elsevier, Edinburgh.
  • Fisher P G (2013) Renal Disorders. In:Clinical Veterinary Advisor. Birds and Exotics Pets. Eds: Mayer J & Donnelly T M. Elsevier, Missouri.
  • Raftery A (2013) Cardiovascular Disease. In:Clinical Veterinary Advisor.Birds and Exotics Pets. Eds: Mayer J & Donnelly T M. Elsevier, Missouri.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website:www.gov.uk/government/collections/veterinary-medicines-guidance-notes-vmgns.

Organisation(s)

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