ISSN 2398-2950      

PIVKA

ffelis
Contributor(s):

Kathleen P Freeman

Synonym(s): Thrombotest, Proteins Induced by Vitamin K


Overview

  • Prolongation of coagulation time absence of or abnormal forms of vitamin-K dependent Factors II, VII and X.

Sampling

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Tests

Methodologies

  • Kit test that is suitable for standard fibrometer or some automated instruments.

Availability

  • Available from some commercial laboratories and/or in-practice testing laboratories.
  • Check with commercial laboratories regarding availability.

Validity

Sensitivity

  • Test has been validated for use in cats.
  • May be more sensitive than PT and/or APTT for detection of absence or antagonism of Vitamin K dependent factors II, VII, and X.

Specificity

  • Not specific for underlying cause of Vitamin K absence or antagonism.

Technique (intrinsic) limitations

  • See quality control factors listed above.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Center S A, Warner K, Corbet J, Randolph J E & Erb H N (2000) Proteins invoked by vitamin K absence and clotting times in clinically ill catsJVIM 14 (3), 292-297.

Other sources of information

  • Rozanski E A, Drobatz K J, Hughes D, Scottie M & Giger U (1998) Thrombotest (PIVKA), Prothrombin Time and Activated Thromboplastin Time Results in 25 Dogs with Acquired and Hereditary Coagulopathies. In: Proceedings 16th Annual ACVIM Forum. San Diego, CA, USA. Abstract No. 183.

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