Felis ISSN 2398-2950

Blood biochemistry: ionized calcium

Contributor(s): Penney Barber, David Bruyette, Kathleen P Freeman

Overview

  • Calcium is present in blood in three compartments:
    • Plasma protein bound.
    • Complexed with small anions.
    • Free ionized.
  • Ionized form is biologically active.
  • Ionized calcium comprizes approximately 50% total calcium.
  • Normal range for ionized calcium is very narrow.
  • Total calcium Blood biochemistry: total calcium tends to reflect ionized calcium but this may not always be particularly true in renal failure Kidney: chronic kidney disease or animals with abnormal protein concentrations.

Sampling

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Tests

Methodologies

  • Potassium chloride-saturated ion-specific electrode analysis.

Availability

  • Available at some commercial laboratories and local hospitals (although reference values would need to be established for animals).
  • In-house bench top analyzers can be purchased.
  • Hand-held patient-side analyzers available.

Technique (intrinsic) limitations

  • Simple technique.

Result Data

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


ADDED