Felis ISSN 2398-2950

Blood biochemistry: direct bilirubin

Synonym(s): Conjugated bilirubin

Contributor(s): Kathleen P Freeman

Overview

  • Serum bilirubin is a mixture of direct (conjugated) and indirect (unconjugated) bilirubin.
  • Peripheral breakdown of red cells and myoglobin   →   unconjugated bilirubin   →   (liver) conjugated with glucuronic acid   →   excreted in bile as conjugated (direct) bilirubin.
  • However, conjugated hyperbilirubinemia occurs in even in hemolytic disease.
    In animals there is little evidence that the ratio of direct to indirect bilirubin is diagnostically significant.

Sampling

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Tests

Methodologies

  • Van den Bergh method.

Availability

  • Routine test.

Validity

Sensitivity

  • Van den Bergh test relatively insensitive.

Technique (intrinsic) limitations

  • Most useful when interpreted in conjunction with other laboratory and clinical findings.

Result Data

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Anderson J G & Washabau (1992) Icterus. Comp Cont Educ Pract Vet 14(8), 1045-1061.
  • Engelking L R (1988) Disorders of bilirubin metabolism in small animal species. Comp Contin Educ Pract Vet 10, 712.

Other sources of information

  • Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
  • Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
  • Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.


ADDED