Felis ISSN 2398-2950

Torasemide

Synonym(s): UpCard, Isemid, torsemide

Contributor(s): Vetstream Ltd, Liz Bode

Introduction

Name

  • Torasemide. 

Class of drug

  • Loop diuretic of the pyridyl sulfonylurea class. 

Description

Chemical name

  • 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea. 

Molecular formula

  • C16H20N4O3S 

Molecular weight

  • 348.42 

Physical properties

  • White to off-white tablets. 

Storage requirements

  • No specific storage requirements. 

Uses

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Indications

For cats in acute crisis with pulmonary edema, pleural effusion and/or ascites requiring emergency treatment, use of injectable furosemide Furosemide should be considered first before commencing oral diuretic therapy Therapeutics: diuretics

Administration

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Precautions

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Interactions

With other drugs

  • Co-administration of loop diuretics and NSAIDs Analgesia: NSAID can result in a decreased natriuretic response. 
  • Concomitant use with: 
    • Drugs affecting electrolyte balance (corticosteroids, amphotericin B Amphotericin B, cardiac glycosides, other diuretics) requires careful monitoring. 
    • Drugs that increase risk of renal injury or insufficiency should be avoided. 
    • Aminoglycosides or cephalosporins may increase risk of nephrotoxicity and ototoxicity. 
    • Other drugs metabolized by cytochrome P450 families may decrease their clearance, eg enalapril Enalapril, buprenorphine Buprenorphine, doxycycline Doxycycline, cyclosporine Ciclosporin, isoflurane Isoflurane, sevoflurane Sevoflurane, theophylline Theophylline). 
  • May increase risk of sulphonamide allergy. 
  • Can reduce renal excretion of salicylates, leading to an increased risk of toxicity. 
  • Antihypertensive drugs (especially ACE inhibitors) may be potentiated with co-administered with torasemide. 

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed
  • Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y (2003) The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats.  J Vet Med Sci 65(10), 1057-1061 PubMed

Other sources of information


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