Felis ISSN 2398-2950

Sevoflurane

Synonym(s): Sevo

Contributor(s): John Dodam, Sheilah Robertson

Introduction

Class of drug

  • Halogenated inhalation anesthetic drug.

Description

Chemical name

  • Fluoromethyl 2,2,2-trifluoro-l-(trifluoromethyl)ethyl ether.

Molecular formula

  • CH2F-O-CH(CF3)-CF3

Molecular weight

  • 200

Physical properties

  • Boiling point 58.5°C.
  • Volatile liquid, clear, colorless, non-pungent.
  • Saturated vapor.
  • Blood-gas partition coefficient of 0.7.
  • Pressure at 20°C of 160 mmHg.

Storage requirements

  • Store in manufacturers amber colored bottles.
  • Store at room temperature (15-30°C).

Uses

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Indications

  • Approved for the induction and maintenance of anesthesia in dogs only.
  • Not approved for use in cats although is widely used in cats in clinical practice.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Interacts with desiccated carbon dioxide (soda lime and barium hydroxide lime) absorbents to produce carbon monoxide and Compound A.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Mendes G M, Selmi A L, Barbudo-Selmi G R, Lins B T & Figueiredo J P (2003) Clinical use of dexmedetomidine as premedicant in cats undergoing propofol-sevoflurane anaesthesiaJ Feline Med Surg 5(5), 265-270 PubMed DOI.
  • Lerche P, Muir WW & Grubb TL (2002) Mask induction of anaesthesia with isoflurane or sevoflurane in premedicated cats. J Small Anim Pract 43(1), 12-15.
  • Branson KR et al(2001) A multisite case report on the clinical use of sevoflurane in dogsJ Am Anim Hosp Assoc 37(5), 420-432.
  • Clarke KW (1999) Desflurane and sevoflurane. New volatile anesthetic agents. Vet Clin North Am Small Anim Pract 29(3), 793-810.
  • Hikasa Y, Ohe N, Takase K & Ogasawara S (1997) Cardiopulmonary effects of sevoflurane in cats: comparison with isoflurane, halothane, and enflurane. Res Vet Sci 63(3), 205-210.
  • Hikasa Y, Kawanabe H, Takase K & Ogasawara S (1996) Comparisons of sevoflurane, isoflurane, and halothane anesthesia in spontaneously breathing cats. Vet Surg 25(3), 234-243.

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