ISSN 2398-2950      

Selamectin

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Introduction

Name

  • Selamectin.

Class of drug

  • Avermectin parasiticide.

Description

Chemical name

  • (5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(2-methylpropyl)-22,23-dihydro-5-hydroxyiminoavermectin A1a.

Molecular formula

  • C43 H63 NO11.

Molecular weight

  • 770.0.

Physical properties

  • White powder.

Storage requirements

  • Store in the unopened foil package in a dry place.
  • Do not store above 30°C.
  • Highly flammable: keep away from heat, sparks, open flames or other sources of ignition.

Uses

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Indications

Dogs, cats
  • Treatment and prevention of flea infestation caused byCtenocephalides spp  Ctenocephalides felis  .
  • As part of strategy for treatment of flea allergy dermatitis   Flea bite hypersensitivity  .
  • Prevention of heartworm disease caused byDirofilaria immitiswith monthly administrations.

Dogs

  • Treatment of sarcoptic mange caused bySarcoptes scabiei  Sarcoptes scabiei  .
  • Treatment of adult intestinal roundworms (Toxocara canis).
  • Control of tick (Dermacentor variabilis) infestations.

Cats

  • Treatment of ear mites   Otodectes disease  (Otodectes cynotis  Otodectes cynotis  ).
  • Treatment of adult intestinal roundworms (Toxocara cati  Toxocara cati  ).
  • Treatment of adult intestinal hookworms (Ancylostoma tubaeforme).

Administration

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Pharmacokinetics

Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource
  • Blot C et al (2003) Efficacy of selamectin administered topically in the treatment of feline otoacarosisVet Parasitol 112, 241-247.
  • Dickin S K et al (2003) Efficacy of selamectin in the treatment and control of clinical signs of flea allergy dermatitis in dogs and acts experimentally infected with fleasJAVMA 223, 639-644.
  • McTier T L et al (2003) Comparison of the activity of selamectin, fipronil and imidacloprid against flea larvae (C. felis felis) in vitroVet Parasitol 116, 45-50.
  • Itoh N, Muraoka N, Aoki M & Itagaki T (2004) Treatment ofNotoedres catiinfestation in cats with selamectin. Vet Rec 154, 409.
  • Benchaoui H A et al (2000) Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe. Vet Parasitol 91, 223-232.
  • Bishop B Fet al (2000) Selamectin - a novel broad-spectrum endectocide for dogs and cats. Vet Parasitol 91, 163-176.
  • Boy M G et al (2000) Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Vet Parasitol 91, 233-250.
  • Clemence R G et al (2000) Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy. Vet Parasitol 91, 251-258.
  • Jernigan A D et al (2000) Efficacy of selamectin against experimentally induced tick (Rhipicephalus sanguineus and Dermacentor variabilis) infestations on dogs. Vet Parasitol 91, 359-376.
  • Krautmann M J et al (2000) Safety of selamectin in cats.Vet Parasitol 91, 393-404.
  • McTier T L et al (2000) Dose selection of selamectin for efficacy against adult fleas (Ctenocephalides felis felis) on dogs and cats.Vet Parasitol 91, 177-186.
  • McTier T L et al (2000) Efficacy of selamectin against adult flea infestations (Ctenocephalides felis felis and Ctenocephalides canis) on dogs and cats. Vet Parasitol 91, 187-200.
  • McTier T L et al (2000) Evaluation of the effects of selamectin against adult and immature stages of fleas (Ctenocephalides felis felis) on dogs and cats. Vet Parasitol 91, 201-212.
  • McTier T L et al (2000) Prevention of experimentally induced heartworm (Dirofilaria immitis) infections in dogs and cats with a single topical application of selamectin. Vet Parasitol 91, 259-268.
  • McTier T L et al (2000) Efficacy of selamectin against experimentally induced and naturally acquired infections of Toxocara cati and Ancylostoma tubaeforme in cats. Vet Parasitol 91, 311-320.
  • McTier T L et al (2000) Efficacy of selamectin against experimentally induced and naturally acquired ascarid (Tosocara canis and Toxocaris leonina) infections in dogs. Vet Parasitol 91, 333-346.
  • Novotny M J et al (2000) Safety of selamectin in dogs.Vet Parasitol 91, 377-392.
  • Payne-Johnson M et al (2000) Efficacy of selamectin administered topically to pregnant and lactating female dogs in the treatment and prevention of adult roundworm (Toxocara canis) infections and flea (Ctenocephalides felis felis) infestations in the dams and their pups. Vet Parasitol 91, 347-358.
  • Shanks D K et al (2000) Efficacy of selamectin in the treatment and prevention of flea (Ctenocephalides felis felis) infestations on dogs and cats housed in simulated home environments. Vet Parasitol 91, 213-222.
  • Shanks D J et al (2000) The efficacy of selamectin in the treatment of naturally acquired infestations of Sarcoptes scabiei on dogs. Vet Parasitol 91, 269-282.
  • Shanks D J et al (2000) The efficacy of selamectin in the treatment of naturally acquired aural infestations of Otodectes cynotis on dogs and cats. Vet Parasitol 91, 283-290.
  • Six R H et al (2000) Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients. Vet Parasitol 91, 291-310.
  • Six R H et al (2000) Efficacy and safety of selamectin against gastrointestinal nematodes in cats presented as veterinary patients. Vet Parasitol 91, 321-332.

Other sources of information

  • Benchaoui H et al (1999) Efficacy of UK-124,114 against nematodes in cats. Proc World Assoc Adv Vet Parasitol, August 16-19; Copenhagen, Denmark.
  • Clemence R G et al (1999) The efficacy of selamectin against mite and tick infestations on dogs and cats. Proc Pfizer Symp held at World Assoc Adv Vet Parasitol, August 16-19; Copenhagen, Denmark.
  • Ritzhaupt L et al (1999) Efficacy of selamectin, fipronil, and lufenuron against Ctenocephalides felis in cats. Proc Am Assoc Vet Parasitol, July 10-13, New Orleans, LA, USA.
  • Ritzhaupt L et al (1999) Efficacy of selamectin, fipronil, imidacloprid, and lufenuron/milbimycin against Ctenocephalides felis in dogs. Proc Am Assoc Vet Parasitol, July 10-13, New Orleans, LA, USA.
  • Six R H et al (1999) Efficacy of selamectin against induced and natural infections of Toxocara cati and Ancylostoma tubaeforme in cats. Proc Am Assoc Vet Parasitol, July 10-13; New Orleans, LA, USA.
  • Sture G H (1999) Efficacy of selamectin against Sarcoptes spp in veterinary patients in the UK. Proc Eur Soc Vet Derm, August 12-14; Helsinki, Finland.
  • Thomas C A et al (1999) Efficacy of selamectin against natural infestations of Sarcoptes scabiei and Otodectes cynotis in dogs and cats. Proc Am Assoc Vet Parasitol, July 10-13, New Orleans, LA, USA.
  • Wren J A et al (1999) Efficacy of selamectin against Toxocara canis in dogs. Proc Am Assoc Vet Parasitol, July 10-13, New Orleans, LA, USA.
  • McTier T L et al (1998) Efficacy of UK-124,114, a novel avermectin, for the prevention of heartworms in dogs and cats. Proc Am Heartworm Soc Symp, May 1-3; Tampa, FL, USA.
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