ISSN 2398-2950      

Rifampicin

ffelis
Contributor(s):

Sally Anne Argyle

Jo Murrell

Synonym(s): Rifampin


Introduction

Name

  • Rifampicin.

Class of drug

  • Rifampicin belongs to the class Rifamycin and is a bacteriocidal antibiotic that is a semi-synthetic derivative of the naturally occurring antibiotic rifamycin B.

Description

Chemical name

  • Rifampicin.

Molecular formula

  • C43H58N4O12

Molecular weight

  • 822.94

Uses

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Indications

  • It is particularly effective against Gram-positive organisms, some mycobacteria, Chlamydophila   Chlamydophila felis  ,Rickettsia, some protozoans and poxviruses   Cat pox virus  .
  • It is most commonly used to treatMycobacterium tuberculosis  Mycobacterium tuberculosis  ,Rhodococcus andStaphylococciinfections   Staphylococcus spp  .
  • Gram-negative aerobic bacteria are usually resistant to rifampicin but obligate anaerobic bacteria are usually susceptible.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Rifampicin is a potent hepatic P450 cytochrome enzyme inducer and increases rate of metabolism of other drugs in man including barbiturates, theophylline   Theophylline   and ketoconazole   Ketoconazole  . Increased dosages of these drugs may be required if used in combination with rifampicin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Riviere D, Pingret J-L, Etievant M, Jechoux A, Lanore D, Raymond-Letron I, Boucraut-Baralon (2011) Disseminated Mycobacterium avium subspecies infection in a cat. J Fel Med Surg 13, 125-128 PubMed.

Other sources of information

  • The Veterinary Formulary (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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