Felis ISSN 2398-2950

Propantheline

Contributor(s): Lauren Trepanier, Vetstream Ltd

Introduction

Name

  • Propantheline bromide.

Class of drug

  • Quarternary ammonium antimuscarinic agent.

Uses

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Indications

  • Incontinence caused by detrusor hyperreflexia.
  • May occasionally be useful in treating bradycardias .
  • A peripherally acting anti-emetic (not recommended).
  • Occasionally used as an adjunctive therapy to treat diarrhea (not recommended due to side-effects of ileus).

Administration

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Precautions

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Interactions

with other drugs

Antihistamines, benzodiazepines, pethidine, phenothiazines, procainamide and quinidine

  • May enhance the activity of propantheline and its derivatives.

Chronic corticosteroid use (may increase intra-ocular pressure), disopyramide, nitrates and primidone

  • May potentiate the adverse effects of propantheline and its derivatives.

Nitrofurantoin, sympathomimetics and thiazide diuretics

  • Propantheline and its derivatives may enhance the actions.

Metoclopropamide

  • Propantheline and its derivatives may antagonize the actions.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 

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