ISSN 2398-2950      

Procainamide

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Introduction

Name

  • Procainamide.

Class of drug

  • Class 1a antidysrhythmic agent.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

Other antiarrhythmic agents
  • Increased myocardial depression may develop.
    Anticholinesterases (eg pyridostigmine)
  • May be antagonized by procainamide.
    Hypotensive drugs
  • May be potentiated by procainamide.
    Cimetidine
  • Inhibits the metabolism of procainamide and decreases the renal clearance of procainamide and NALA (active metabolite), thereby increasing serum levels.
    Neuromuscular blockers (eg suxamethonium)
  • May be potentiated or prolonged by procainamide.
    Agents having neuromuscular blocking activity (eg aminoglycosides)
  • Muscle relaxant effect may be potentiated or prolonged by procainamide.
    Digoxin
  • See'Use with care'.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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