Felis ISSN 2398-2950

Pilocarpine

Contributor(s): Sheryl Krohne, Natasha Mitchell

Introduction

Name

  • Pilocarpine.

Class of drug

  • Direct-acting parasympathomimetic agent.

Uses

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Indications

  • Pharmacological testing for diagnosis of feline dysautonomia Dysautonomia.
  • Neurogenic keratoconjunctivitis sicca Eye: keratoconjunctivitis sicca (KCS). Oral use has been reported to notably increase STT readings Schirmer tear test, but needed to be discontinued due to systemic side-effect of gastrointestinal disturbance (Sebbag et al, 2018).
  • Management of primary glaucoma Glaucoma. However, this drug is now rarely used for glaucoma in veterinary ophthalmology with the availability of more effective and better-tolerated medication.
  • Penetrates the cornea producing miosis within 15 min and is effective for 6-8 hours.

Administration

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Sebbag L, Pesavento P A, Carrasco S E, Reilly C M, Maggs D J (2018) Feline dry eye syndrome of presumed neurogenic origin: a case report. JFMS Open Rep Jan 2;4(1) doi: 10.1177/2055116917746786 Full Article PubMed.
  • McLellan G J, Miller P E (2011) Feline glaucoma - a comprehensive review. Vet Ophthalmol 14 Suppl 1,15-29 PubMed.

Other sources of information

  • Stiles J (2013) Feline Ophthalmology. In: Veterinary Ophthalmology. T J Kern & K Gelatt (eds), 5th edn, Chapter 27, pp 1477-1558.
  • Based on Tennant B (1999) Small Animal Formulary. 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
  • Regnier A & Ward D (1999) Clinical Pharmacology and Therapeutics. In:Veterinary Ophthalmology 3rd edn. Ed: K N Gelatt. Baltimore: Lippincott, Williams and Wilkins. ISBN: 0 6833 0076 8.
  • Plumb D (1999) Veterinary Drug Handbook. 3rd edn. Ames: Iowa State University Press. ISBN: 0 8138 2353 6.

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