Felis ISSN 2398-2950

Oxymorphone

Synonym(s): oxy

Contributor(s): John Dodam, Sheilah Robertson

Introduction

Name

  • Oxymorphone hydrochloride.

Class of drug

Description

Chemical name

  • 7,8-dihydro-14hydroxymorphinone hydrochloride

Molecular weight

  • 337.80

Physical properties

  • White, odorless powder.
  • Soluble in water.

Storage requirements

  • At 15-30°C.
  • Protect from light.

Uses

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Indications

  • To provide pain relief.
  • Can be used pre-emptively for elective surgical procedures.
  • Can be used to relieve pain from trauma.
  • Has also been used to provide longer-term pain relief, eg that caused by osteosarcoma.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can cause profound sedation when combined with acepromazine Acepromazine maleate  , alpha2-agonists (xylazine Xylazine, medetomidine Medetomidine) and benzodiazepines.
  • Oxymorphone may reduce the induction dose of injectable anesthetic agents and lower the dose of inhalant agents required for maintenance of anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Dobbins S, Brown N O & Shofer F S (2002) Comparison of the effects of buprenorphine, oxymorphone hydrochloride and ketoprofen for post-operative analgesia after onychectomy or onychectomy and sterilization in cats. JAAHA 38(6), 507-514.
  • Pascoe PJ (2000) Opioid analgesicsVet Clin North Am Small Anim Pract 30(4), 757-772.
  • Briggs S L, Sneed K & Sawyer D C (1998) Antinociceptive effects of oxymorphone-butorphanol-acepromazine combination in cats.Vet Surg 27(5), 466-472.

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