ISSN 2398-2950      

Morphine

ffelis

Synonym(s): morphine sulfate


Introduction

Name

  • Morphine.

Class of drug

  • Opioid analgesic.
  • Schedule II Controlled Substance.
  • Mu receptor agonist.

Description

Chemical name

  • (5-alpha,6-alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol

Molecular formula

  • C17H19NO3

Physical properties

  • Tablets.
  • Solution.

Storage requirements

Uses

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Indications

Not licensed in the UK – methadone Methadone is licensed and is a suitable alternative to morphine for premedication and peri-operative analgesia.

Administration

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Precautions

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Interactions

with other drugs

CNS depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)

  • Enhanced central nervous system (CNS) or respiratory depression may occur.

with diagnostic tests

Plasma amylase or lipase

  • As narcotic analgesics can increase biliary tract pressure, levels may be increased for up to 24 hours after drug administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Jones R S (2001) Epidural analgesia in the dog and cat. Vet J 161(2), 123-131.
  • Dohoo S E & Dohoo I R (1998) Attitudes and concerns of Canadian animal health technologists toward postoperative pain management in dogs and cats. Can Vet J 39(8), 491-496.

Other sources of information

  • Based on Small Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook.3rd edn. Iowa State University Press, Ames. pp 440-443
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