ISSN 2398-2950      

Methylprednisolone

ffelis
Contributor(s):

Vetstream Ltd


Introduction

Name

  • Methylprednisolone.

Class of drug

  • Corticosteroid.

Uses

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Indications

  • Anti-inflammatory suitable for alternate day use.
  • Treatment for shock.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (Furosemide, thiazides)

  • Hypokalemia may develop.

Insulin

  • Insulin requirements are likely to increase.

Phenobarbital or phenytoin

  • The metabolism of corticosteroids may be enhanced.
  • Increased risk of gastrointestinal ulceration if used concurrently with NSAIDs.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.
  • Will increase steroid induced alkaline phosphatase in dogs.
  • Some cross reaction with cortisol assay. May interfere with interpretation of other tests eg ACTH stimulation test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Ferasin L (2001) Iatrogenic hyperadrenocorticism in a cat following a short therapeutic course of methylprednisolone acetate. JFMS 3, 87-93.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.
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