ISSN 2398-2950      

Methimazole

ffelis
Contributor(s):

Laura Johnston

Synonym(s): Thiamazole


Introduction

Class of drug

  • Thiourelyene anti-thyroid drug.

Description

Chemical name

  • Methimazole (thiamazole).

Molecular formula

  • C4H6N2S

Molecular weight

  • 114.17

Storage requirements

  • Do not store above 25°C.
  • Protect from moisture.

Uses

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Indications

  • Stabilization of hyperthyroidism   Hyperthyroidism   before surgical thyroidectomy   Thyroidectomy  .
  • Long-term control of feline hyperthyroidism.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Phenobarbitone may decrease efficacy of methimazole.
  • Benzimidazole wormers decrease hepatic oxidation of these actives and may lead to increased circulating levels.
  • Thiamazole is immunomodulatory therefore this should be taken into account when considering vaccination programs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Fischetti A J, Drost W T, DiBartola S P, Chew D J, Schenck P A, Meadows C (2005) Effects of methimazole on thyroid gland uptake of 99mTC-pertechnetate in 19 hyperthyroid cats. Vet Radiol Ultrasound 46 (3), 267-272 PubMed.
  • Sartor L L, Trepanier L A, Kroll M M, Rodan I, Challoner L (2004)
  • Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. J Vet Intern Med 18 (5), 651-655 PubMed.
  • Trepanier L A, Hoffman S B, Kroll M, Rodan I, Challoner L (2003) 
  • Efficacy and safety of once versus twice daily administration of methimazole in cats with hyperthyroidism. JAVMA 222 (7), 954-958 PubMed.
  • Hoffmann G, Marks S L, Taboada J, Hosgood G L, Wolfsheimer K J (2003)Transdermal methimazole treatment in cats with hyperthyroidism. J Feline Med Surg (2), 77-82 PubMed.
  • Nieckarz J A, Daniel G B (2001) The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. Vet Radiol Ultrasound 42 (5), 448-457 PubMed.
  • Becker T J, Graves T K, Kruger J M, Braselton W E, Nachreiner R F (2000) Effects of methimazole on renal function in cats with hyperthyroidism. JAAHA 36 (3), 215-223 PubMed.
  • Peterson M E, Aucoin D P (1993) Comparison of the disposition of carbimazole and methimazole in clinically normal cats. Res Vet Sci 54 (3), 351-355 PubMed.
  • Trepanier L A, Peterson M E, Aucoin D P (1991) Pharmacokinetics of methimazole in normal cats and cats with hyperthyroidism. Res Vet Sci 50 (1), 69-74 PubMed.
  • Peterson M E, Kintzner P P & Hurvitz A I (1988) Methimazole treatment of 262 cats with hyperthyroidismJ Vet Int Med 2, 150-157 PubMed.
  • Burden & Rosenthal (1983) Methimazole and insulin autoimmune syndrome. The Lancet (2), 1311 PubMed.
  • Hirata (1983) Methimazole and Insulin Autoimmune Syndrome with hypoglycaemia. The Lancet (2), 1037-1038 PubMed.

Other sources of information

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