ISSN 2398-2950      

Lomustine

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Synonym(s): CeeNU, CCNU


Introduction

Name

  • Lomustine.

Class of drug

  • Alkylating agent in the nitrosurea family.

Description

Chemical name

  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosurea.

Molecular formula

  • C9H16C1N3O2

Molecular weight

  • 233.71

Physical properties

  • Yellow powder.

Storage requirements

  • Stable if stored in well closed containers at room temperature until expiration date indicated on package. Avoid excessive heat over 40°C.

Uses

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Indications

  • Granulomatous meningioencephalitis (GME), other inflammatory CNS diseases.
  • Indicated as a single agent or as part of combination therapy in the treatment of high grade or metastatic mast cell tumors   Mastocytoma  , epitheliotropic or refractory lymphoma   Lymphoma   and multiple myeloma   Multiple myeloma  .

Administration

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Pharmacokinetics

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Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Saba C F, Thamm D H & Vail D M (2009) Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma. JVIM 23 (5), 1058-1063 PubMed.
  • Rassnick K M et al (2008) Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005). JAVMA 232 (8), 1200-1205 PubMed.
  • Kristal O et al (2004) Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. JVIM 18 (1), 75-80 PubMed.
  • Fan T M et al (2002) Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen. JAAHA 38 (4), 357-363.
  • Rassnick K M et al (2001) Phase 1 evaluation of CCNU (lomustine) in tumor-bearing cats. JVIM 15 (3), 196-199 PubMed.

Other sources of information

  • Tennant B (2005) BSAVA Small Animal Formulary. 5th edn. Quedgeley, UK.
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