ISSN 2398-2950      

L-asparaginase

ffelis
Contributor(s):

Vetstream Ltd

Synonym(s): Crisantaspase


Introduction

Name

  • L-asparaginase.

Class of drug

  • Enzyme.

Description

Chemical name

  • L-asparaginase - enxyme derived from Escherichia coli.
  • Crisantaspase - enzyme derived from Erwinia chrysoanthemi.
  • PEG-asparaginase - enzyme derived from Vibrio succinogenes.

Molecular weight

  • 133,000 daltons.

Physical properties

  • White powder comprising 10,000 IU per vial for reconstitution with 2-5 ml sterile water.

Storage requirements

  • Short shelf-life after reconstitution.

Uses

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Indications

  • Cytotoxic agent.
    • Acute lymphocytic leukemia   Acute lymphoblastic leukemia.
    • Lymphoma Lymphoma (in combination with other chemotherapies) in dogs (although some cats have responded to treatment).
    • Granulomatous dermatitis.
    • Mast cell tumors Mastocytoma in dogs.
    • Melanomas in dogs.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Bishop Y M (1996) Ed. The Veterinary Formulary. Handbook of Medicines Used in Veterinary Practice. 3rd edn. Royal Pharmaceutical Society of Great Britain and British Veterinary Association, UK. pp 334-335. ISBN 0 85369 345 5.
  • Brander G C, Pugh D M, Bywater R J & Jenkins W L (1991) Veterinary Applied Pharmacology and Therapeutics. 5th edn. Bailliere Tindall, UK. pp 400. ISBN 0 7020 1366 8.
  • Einstein R, Jones R S, Knifton A & Starmer G A (1994) Principles of Veterinary Therapeutics. Longman Scientific and Technical, UK. pp 538. ISBN 0 582 02963 5.
  • Couto C G and Hammer A S (1994) Oncology. In: The Cat. Diseases and Clinical Management. Volume 1. 3rd edn. Ed R G Sherding. Churchill Livingstone, USA. pp 767 & 786. ISBN 0 443 08879 9.
  • Mehta D K (1999) Executive Ed. Electronic British National Formulary, Number 33. British Medical Association, Royal Pharmaceutical Society of Great Britain and Quartet Software Ltd, UK.
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