ISSN 2398-2950      

Ketoconazole

ffelis
Contributor(s):

Stephen Barr

Vetstream Ltd


Introduction

Name

  • Ketoconazole.

Class of drug

  • Imidazole antifungal agent.

Uses

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Indications

  • Used to treat aspergillosis   Aspergillosis  , candidiasis   Candida albicans  , blastomycoses, coccidiomycoses, cryptococcosis   Cryptococcosis  , sporotrichosis and dermatophytosis.
  • It is used in the treatment of hyperadrenocorticism   Hyperadrenocorticism  in dogs that do not tolerate mitotane   Mitotane  and in cats.
    Its efficacy in management of hyperadrenocorticism is variable.

Administration

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Precautions

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Interactions

with other drugs

Drugs increasing pH of gastric contents (eg antacids, antimuscarinics and H2 blockers)

  • The absorption of ketoconazole may be impaired; stagger dosing of these drugs around ketoconazole dose.

Methylpredniselone

Phenytoin

  • Plasma ketoconazole levels are reduced by phenytoin Phenytoin.

Antihistamines, oral hypoglycemics, antiepileptics, cisapride and ciclosporin

  • Antifungal imidazoles and triazoles inhibit metabolism of these drugs but interactions have not been studied in veterinary field.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK.
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