ISSN 2398-2950      

Isoflurane

ffelis
Contributor(s):

Kyle Braund

Vetstream Ltd


Introduction

Name

  • Isoflurane.

Class of drug

  • Inhalational anesthetic.

Description

Physical properties

  • Volatile halogenated ether liquid.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • An inhalational anesthetic General anesthesia: overview.
  • Induction and maintenece of anesthesia for all types of surgery and in all species, irrespective of age.
    Rapid recovery following painful, eg orthopedic procedures, necessitates appropriate and rapid attention to analgesia Analgesia: overview.
  • Assertions that isoflurane is safer in certain high risk cases should be discounted.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Duration of non-depolarizing neuromuscular blocking agents is longer in isoflurane, compared with halothane-anesthetized animals.
  • Opioid agonists, benzodiazepines and nitrous oxide Nitrous oxide reduce the concentration of isoflurane required to acheive surgical anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • March P A, Muir W W 3rd (2003) Minimum alveolar concentration measures of central nervous system activation in cats anesthetized with isoflurane. Am J Vet Res 64 (12), 1528-1233 PubMed.
  • Yackey M, Ilkiw J E, Pascoe P J & Tripp L D (2004) Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats. Vet Anaesth Analg 31 (3), 183-189 DOI.
  • Lerche P, Muir W W & Grubb T L (2002) Mask induction of anaesthesia with isoflurane or sevoflurane in premedicated catsJ Small Anim Pract 43 (1), 12-15.
  • Clarke K W (1999) Desflurane and sevoflurane. New volatile anesthetic agents. Vet Clin North Am Small Anim Pract 29 (3), 793-810.
  • Hikasa Y, Yamashita M, Takase K, Ogasawara S (1998) Prolonged sevoflurane, isoflurane and halothane anaesthesia in oxygen using rebreathing or non-rebreathing system in cats. Zentralbl Veterinarmed A 45 (9), 559-575.

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn.
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK. ISBN: 0 9052 1452 8.
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, USA. pp 348-349.
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