Felis ISSN 2398-2950

Hydromorphone

Contributor(s): John Dodam, Sheilah Robertson

Introduction

Name

  • Hydromorphone hydrochloride.

Class of drug

Description

Molecular formula

  • 4,5±-epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride

Molecular weight

  • 321.80

Physical properties

  • White powder.
  • Freely soluble in water.
  • Semi-synthetic phenanthrene alkaloid of opium.

Storage requirements

  • Store at 15-30°C.
  • Protect from light.

Uses

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Indications

  • Use as an opioid analgesic.
  • A cost-effective alternative to oxymorphone.
  • For the relief of pain.
  • Can be used pre-emptively for elective surgical procedures.
  • Can be used to relieve pain from trauma.
  • Has also been used to provide longer-term pain relief, eg that caused by osteosarcoma.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can cause profound sedation when combined with acepromazine Acepromazine maleate  , alpha2-agonists (xylazine Xylazine, medetomidine Medetomidine) and benzodiazepines.
  • Hydromorphone may reduce the induction dose of injectable anesthetic agents and lower the dose of inhalant agents required for maintenance of anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Pascoe PJ (2000) Opioid analgesics. Vet Clin North Am Small Anim Pract 30(4), 757-772.
  • Pettifer G & Dyson D (2000) Hydromorphone: a cost-effective alternative to the use of oxymorphone. Can Vet J  41(2), 135-137

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