Felis ISSN 2398-2950

Hydrochlorothiazide

Contributor(s): Vetstream Ltd

Introduction

Name

  • Hydrochlorothiazide.

Class of drug

  • Thiazide diuretic.

Uses

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Indications

  • Ascites.
  • Pleural effusion Pleural effusion.
  • Edema.
  • Hypertension Hypertension.
  • When using hydrochlorthiazide to treat hypertension, if potassium loss is/may be a clinical problem, it should be used in combination with a potassium sparing diuretic (eg amiloride).
  • To inhibit lactation in pseudopregnancy.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Corticosteroids

  • Increased possibility of hypokalemia developing.

Digoxin

  • Thiazide-induced hypokalemia may increase the risk of digoxin toxicity Digoxin. Thus, potassium therapy may be necessary during prolonged administration.

Sulfonamides

  • May potentiate thiazide activity.

Quinidine

  • Half-life may be prolonged by thiazides (alkalinizes urine) Quinidine.

Diazoxide

  • Increased chance of hyperglycemia, hyperuricemia and hypotension.

Vitamin D or calcium salts

  • May exacerbate hypercalcemia.

Adverse Reactions

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Further Reading

Publications

efereed Papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (1999) 9th edn. 

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