ISSN 2398-2950      

Hydralazine

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Introduction

Name

  • Hydralazine.

Class of drug

  • Peripheral vasodilator.

Description

Chemical name

  • 1-hydrazinophthalazine HCl.

Molecular weight

  • 197.

Physical properties

  • Odorless crystalline powder.

Storage requirements

  • Room temperature.

Uses

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Indications

  • CHF due to valve disease. Does not benefit patients with myocardial failure.

Administration

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Precautions

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Interactions

with other drugs

Drugs enhancing the hypotensive effects of hydralazine

  • ACE inhibitors, eg enapril.
  • Anesthetics.
  • Beta-blockers, eg propanolol, (enhances oral absorption of propanolol.
  • Calcium channel blockers, eg diltiazem, verapamil (additive hypotensive effect).
  • Corticosteroids.
  • Diuretics.
  • NSAIDs.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Kyles A E, Gregory C R, Wooldridge J D, Mathews K G, Aronson L R, Bernsteen L & Ilkiw J E (1999) Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. Vet Surg 28 (60), 436-441.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. BSAVA, UK.
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press.
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