ISSN 2398-2950      

Furosemide

ffelis
Contributor(s):

Mark Rishniw

Synonym(s): Frusemide, Lasix


Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Storage requirements

  • In light resistant containers.
  • At room temperature.

Uses

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Indications

  • Used in the management of:
    Congestive heart failure
  • Furosemide acutely increases venous capacitance when administered IV.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

ACE inhibitors and digoxin
  • Combination of furosemide, ACE inhibitor and digoxin with a sodium restricted diet may be associated with mild hyperkalemia.
    Theophylline
  • May be enhanced when given with furosemide   Theophylline  .
    Aminoglycosides
  • Nephrotoxicity associated with the aminoglycosides may be potentiated.
    Digoxin
  • Furosemide may induce hypokalemia, thereby increasing the risk of digoxin toxicity   Digoxin  .
    Aspirin
  • The excretion of both drugs may be reduced as they both compete for renal excretory sites; dose reduction may be required   Acetyl salicylic acid  .
    Insulin
  • Furosemide may alter insulin requirements in diabetic patients.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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