Felis ISSN 2398-2950

Fluticasone

Contributor(s): Elizabeth Rozanski, Vetstream Ltd

Introduction

Name

  • Fluticasone propionate.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • S-(fluoromethyl) 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate-17-propionate.

Molecular formula

  • C25H31F3O5S.

Molecular weight

  • 500.57.

Physical properties

  • White powder insoluble in water.

Storage requirements

  • Do not store >30°C (86°F).
  • Do not refrigerate or freeze.
  • Protect from frost and direct sunlight.

Uses

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Indications

  • Fluticasone is used specifically as an inhaled anti-inflammatory agent. The main indication of use in the cat would be in the management of lower airway disease, specifically allergic bronchitis   Allergic bronchitis  /asthma.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with diagnostic tests

  • Endogenous cortisol levels may be suppressed during treatment with fluticasone.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Leemans J, Kirschvink N, Clercx C et al(2012) Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model.Vet J 192(1), 41-48 PubMed.
  • Cohn L A, DeClue A E, Cohen R L et al(2012) Effects of fluticasone propionate dosage in an experimenal model of feline asthma. J Feline Med Surg 12(2), 91-96 PubMed.
  • Kirschvink N, Leemans J, Delvaux F et al(2006) Inhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis. J Feline Med Surg 8(1), 45-54 PubMed.
  • Padrid P (2006) Use of inhaled medications to treat respiratory diseases in dogs and cats. J Am Anim Hosp Assoc 42(2), 165-169 PubMed.

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