ISSN 2398-2950      

Fluoxetine hydrochloride

ffelis

Synonym(s): For veterinary use: Reconcile®; For human use: Prozac®, Sarafem®, Ladose®, Fontex®


Introduction

Name

  • IUPAC.

Class of drug

  • Antidepressant.
  • Selective serotonin re-uptake inhibitor (SSRI) class.

Description

Chemical name

  • (RS)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine.

Molecular formula

  • C17H18F3NO-HCl

Molecular weight

  • 345.79

Physical properties

  • White to off-white crystalline solid.
  • Water Solubility:  14 mg/mL.
  • Octanol-water Partition Coefficient (log P, pH 7) : 4.1.
  • Product as packaged for sale:
    • 8, 16, 32 and 64 mg tablets, in bottles containing 30 tablets - approved for veterinary use in dogs in the US.
    • 10 mg tablets - not approved for veterinary use.
    • 10, 20 and 40 mg tablets - not approved for veterinary use.
    • 4 mg/mL syrup - not approved for veterinary use.

Storage requirements

  • Veterinary product as packaged for sale:
    • Store at 20-25ºC (68-77ºF).
    • Excursions permitted between 15-30ºC (59-86ºF).
    • Do not remove desiccant canister from the bottle.

Uses

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Indications

  • Treatment of inappropriate feline urine marking   Indoor marking  :
    • Approved for use in separation anxiety in dogs in the US.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Mixed function oxidase (cytochrome P450) inhibitor - administer with care with other agents undergoing hepatic metabolism. A washout period of 6 weeks may be required before commencing other treatment due to the long half-lives of fluoxetine and norfluoxetine.
  • Do not be give in combination with a monoamine oxidase inhibitor (MAOI) for example, selegiline hydrochloride   Selegiline hydrochloride   (L-deprenyl) or amitraz   Amitraz  , or within a minimum of 14 days of discontinuing therapy with an MAOI.
  • Do not be given concomitantly with drugs that lower the seizure threshold (eg phenothiazines such as acepromazine   Acepromazine maleate   or chlorpromazine).
  • Use with care concomitantly with aspirin   Acetyl salicylic acid  or other anticoagulants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Pugh C M, Sweeney J T, Bloch C P, Lee J A, Johnson J A & Hovda L R (2013) Selective serotonin reuptake inhibitor (SSRI) toxicosis in cats: 33 cases (2004-2010). J Vet Emerg Crit Care 23, 565-570 PubMed.
  • Gruen ME (2012) Animal behavior case of the month. Urine spraying. J Am Vet Med Assoc 241,1445-1447 PubMed
  • Pachel CL (2011) Animal behavior case of the month. Feline urine marking.JAm Vet Med Assoc 239, 1433-1434 PubMed
  • Mills DS, Redgate SE, Landsberg GM (2011) A meta-analysis of studies of treatments for feline urine spraying. PLoS One 15, 6:e18448.
  • Herron ME (2010) Advances in understanding and treatment of feline inappropriate elimination. Top Companion Anim Med 25, 195-202.
  • Hart BL, Cliff KD, Tynes VV, Bergman L (2005) Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats. J Am Vet Med Assoc 226, 378-382 PubMed.
  • Ciribassi J, Luescher A, Pasloske KS, Robertson-Plouch C, Zimmerman A, Kaloostian-Whittymore L (2003) Comparative bioavailability of fluoxetine after transdermal and oral administration to healthy cats. Am J Vet Res 64, 994-998 PubMed.
  • Pryor PA, Hart BL, Cliff KD, Bain MJ (2001) Effects of a selective serotonin reuptake inhibitor on urine spraying behavior in cats. JAVMA 219, 1557-1561 PubMed.
  • Jochle W (1998) Abnormal behaviors and adaptation problems in dogs and cats and their pharmacological control. Tierarztl Prax Ausg K Klientiere Heimtiere 26, 410-421.

Other sources of information

  • Product information www.drugs.com.
  • Product website www.reconcile.com.
  • BSAVA Small Animal Formulary. I Ramsey (2008) Ed. 6th edn. BSAVA, UK. pp 142-143.
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