ISSN 2398-2950      

Edrophonium

ffelis
Contributor(s):

Kyle Braund

Mark Lowrie


Introduction

Name

  • Edrophonium chloride.

Class of drug

  • Anticholinesterase.

Description

Chemical name

  • N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium chloride.
  • Ethyl(M-hydroxyphenyl) dimethylammonium chloride.

Molecular formula

  • C10H16ClNO.

Physical properties

  • Solution.

Uses

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Indications

  • Diagnosis of myasthenia gravis Myasthenia gravis.
  • Atrial tachycardia (vagal effects).
  • Antagonize non-depolarizing neuromuscular blockade Anesthesia: non-depolarizing neuromuscular blockade.
  • It can be used to monitor treatment for patients on longer-acting anticholinesterase inhibitors as well as to help differentiate over from under dosing. If treatment is inadequate, edrophonium chloride will provide immediate amelioration of signs of weakness, whereas in a cholinergic crisis due to overdose, the signs will be temporarily aggravated.

Administration

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Precautions

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Interactions

with other drugs

  • Edrophonium's cardiac effects may be increased in patients receiving digoxin Digoxin.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Mignan T, Targett M, Lowrie M (2020) Classification of myasthenia gravis and congenital myasthenic syndromes in dogs and cats. J Vet Intern Med 34(5), 1707-1717 PubMed.
  • Mignan T, Garosi L, Targett M, Lowrie M (2020) Long-term outcome of cats with acquired myasthenia gravis without evidence of a cranial mediastinal mass. J Vet Intern Med 34 (1), 247-252 DOI: 10.1111/jvim.15655.
  • Watson P (1994) What is your diagnosis? (myasthenia gravis in a dog). JSAP 35 (6), 284.
  • Sims M H & McLean R H (1990) Use of repetitive nerve stimulation to assess neuromuscular function in dogs. A test protocol for suspected myasthenia gravis. Prog Vet Neurol (3), 311-319.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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