Felis ISSN 2398-2950

Doxorubicin

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Name

  • Doxorubicin.

Class of drug

Uses

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Indications

  • Lymphosarcoma   Lymphoma  .
  • Hemangiosarcoma.
  • Lymphoma, soft tissue sarcomas (including vaccine associated sarcomas) and mammary carcinomas in the cat.
  • It may be used alone or in combination with other antineoplastic therapies.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Digoxin

  • Reduction in serum digoxin Digoxin levels.

Barbiturate

  • Increases plasma clearance of doxorubicin.

Cyclophosphamide  

  • Increases risk of cardiotoxicity and cyclophosphamide Cyclophosphamide -induced cystitis.

Heparin

  • Forms precipitate with Doxorubicin.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Kristal O, Lana S E et al(2001) Single agent chemotherapy with doxorubicin for feline lymphoma: a retrospective study of 19 cases (1994-1997). JVIM 15, 125-130.
  • Peaston A E & Maddison J E (1999) Efficacy of doxorubicin as an induction agent for cats with lymphosarcoma. Aust Vet J 77(7), 442-444.
  • Zwahlen C H, Lucroy M D et al(1998) Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997). JAVMA 213(8), 1144-1149.
  • Hahn K A, Frazier D K et al(1997) Effect of infusion regime on doxorubicin pharmacokinetics in the cat. JAAHA 33(5), 427-433.
  • O'Keefe D A, Sisson D D et al(1993) Systemic toxicity associated with doxorubicin administration in cats. J Vet Intern Med 7(5), 309-317.

Other sources of information

  • Fischer D S, Knobf M T et al(2003) The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 109-111.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
  • Plumb D (1999) Veterinary Drug Handbook. 3rd Edn. Iowa State University Press.
  • Fraizier D L & Hahn K A (1995 )Commonly Used Drugs. In: Hahn K A & Richardson R C (eds) Cancer Chemotherapy A Veterinary Handbook. Philadelphia, PA. Williams & Wilkins. pp 102-103.

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