Felis ISSN 2398-2950

Dobutamine

Contributor(s): Mark Rishniw, Vetstream Ltd

Introduction

Name

  • Dobutamine.

Class of drug

  • Principally a beta 1-adrenoceptor agonistwith lesser degrees of alpha1 and beta2 agonist effects.

Description

Chemical name

  • 1,2-benzenediol,4-[2-[3-(4-hydroxyphenyl)-1-methylpropyl] amino]ethyl]-,HCl

Molecular weight

  • 301

Physical properties

  • crystalline powder

Storage requirements

  • Reconstituted IV solution is stable for 24 hours although a slight color change may occur during this period.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Beta-blockers (eg propranolol)

  • Dobutamine may be ineffective if beta-blockers Propranolol have recently been given

Nitroprusside

  • A synergistic effect on the improvement of cardiac output has been recorded with nitroprusside Nitroprusside.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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