ISSN 2398-2950      

Cyproheptadine

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Introduction

Name

  • Cyproheptadine hydrochloride.

Class of drug

  • Antihistamine.
  • Serotonin antagonist.

Description

Physical properties

  • White powder - water-soluble.

Storage requirements

  • At room temperature.

Uses

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Indications

  • Symptomatic relief of allergic skin disease.
  • Appetite stimulation in cats.
  • Aid in management of feline asthma   Allergic bronchitis  .
  • Adjunctive therapy in treatment of hyperadrenocorticism   Hyperadrenocorticism  .

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Additive CNS effects with barbiturates.
  • Monoamine oxidase inhibitors intensify anticholinergic effects.

with diagnostic tests

  • Increases serum amylase concentrations in association with thyrotropin releasing hormone.
  • Decreases reaction to intradermal allergen testing.
    Discontinue for 7-10 days before performing test.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Garcia G, DeMora F, Ferrer L & Puigdemont A (1997) Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells. Am J Vet Res 58 (3), 293-297.
  • Peterson M E & Kintzer P P (1994) Medical treatment of pituitary-dependent hyperadrenocorticism in dogs. Semin Vet Med Surg (Small Anim) (3), 127-131.
  • Scott D W, Miller W H Jr & Cayatte S M (1992) Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs - result of double-blinded, placebo-controlled study. Cornell Vet 82 (3), 247-251.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
  • Plumb D Veterinary Drug handbook. 3rd edn. pp 190-192.
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