Felis ISSN 2398-2950

Clopidogrel

Synonym(s): Plavix

Contributor(s): Vetstream Ltd, Liz Bode

Introduction

Name

  • Clopidogrel. 

Class of drug

  • Anti-platelet. 
  • Anti-coagulant.

Description

Chemical name

  • (+)-(S)-Methyl α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c] pyridine-5(4H)-acetate hydrochloride.

Molecular formula

  • C16H16ClNO2S·HCl

Molecular weight

  • 419.9

Physical properties

  • White to off-white/yellow crystalline powder (almost insoluble in water at pH 7 but freely soluble at pH 1). 

Storage requirements

  • No special storage requirements if in aluminium blisters. 
  • Loose tablets store in a tight, light resistant container. 

Uses

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Indications

  • Prophylaxis against thromboembolism in predisposed dogs.  
  • Adjunctive therapy in autoimmune hemolytic anemia in dogs.  
  • To prevent thrombus formation.  
  • The FATCAT study suggests clopidogrel is superior to aspirin in prevention of recurrent thromboembolic episodes secondary to cardiac disease. 

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Bleeding risk is increased when clopidogrel is combined with aspirin or anticoagulants. 
  • Non-steroidal anti-inflammatory drugs, warfarin Warfarin and selective serotonin reuptake inhibitors increase risk of bleeding in people.  
  • Drugs that alter the activity of the cytochrome P450 enzymes may alter pharmacokinetics of clopidogrel.

With diagnostic tests

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • Blais M C, Bianco D, Goggs R, Lynch A M, Palmer L, Ralph A, Sharp C R (2019) Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 3-Defining antithrombotic protocols. J Vet Emerg Crit Care (San Antonio) 29(1), 60-74 PubMed.
  • Lee P M, Faus M C L, Court M H (2019) High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism. J Vet Pharmacol Ther 42(1), 16-25 PubMed.
  • Teuber M, Mischke R (2016) Influence of a low dosage of clopidogrel on platelet function in cats as measured by the platelet function analyser PFA-100 and the multiplate analyser. Res Vet Sci 109, 149-156 PubMed.
  • Mellett A M, Nakamura  R K, Bianco A (2011) Prospective Study of Clopidogrel Therapy in Dogs with Primary Immune‐Mediated Hemolytic Anemia. JVIM 25(1), 71-75 PubMed.
  • Brainard B M, Kleine S A, Papich M G, Budsberg S C (2010) Pharmacodynamic and pharmacokinetic evaluation of clopidogrel and the carboxylic acid metabolite SR 26334 in healthy dogs. Am J Vet Res 71(7), 822-830 PubMed.
  • Hogan D F, Andrews D A, Green H W et al (2004) Antiplatelet effects and pharmacodynamics of clopidogrel in cats.  J Am Vet Med Assoc 225(9), 1406-1411PubMed.

Other sources of information

  • Hogan D, Fox P, Jacob K et al (2013) Analysis of the Feline Arterial Thromboembolism: Clopidogrel vs. Aspirin Trial (FAT CAT).  Proceedings: ACVIM 2013. 

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk

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