ISSN 2398-2950      

Clomipramine hydrochloride

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Synonym(s): Clomipramine


Introduction

Name

  • Clomipramine.

Class of drug

  • Tricyclic antidepressant.

Description

Chemical name

  • 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine; 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine.

Molecular formula

  • C19H23ClN2.

Storage requirements

  • Store below 30°C.
  • Keep dry.

Uses

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Indications

  • May be useful in the management of obsessive-compulsive feline behaviors such as tail chasing, fly biting, flank sucking, licking associated with lick granulomas.
  • Separation anxiety in dogs.
  • Elimination problems   Indoor toileting  in cats.
  • It should be used in combination with behavioral therapy for separation related disorders manifested by destruction and inappropriate urination and defecation   Indoor toileting    Indoor marking  .

Administration

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Precautions

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Interactions

with other drugs

Anesthetics, anti-arrhythmics
  • Concurrent use increases the risk of arrhythmias.

Anti-epileptics

  • Clomipramine antagonizes the effects of anti-epileptic drugs.

Sedatives

  • Enhances the effects of sedative drugs.
  • Do not use in conjunction with monoamine oxidase inhibitors.
  • Certain drugs such as phenytoin   Phenytoin  may have increased plasma levels if used simultaneously.
  • May potentiate the effects of quinidine   Quinidine  , anticholinergic drugs, eg atropine   Atropine  ), other drugs acting on the CNS and sympathomimetics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Landsberg G M (2001) Clomipramine - beyond separation anxiety. JAAHA 37 (4), 313-318.
  • Seksel K & Lindeman M J (1998) Use of clomipramine in the treatment of anxiety-related and obsessive-compulsive disorders in cats. Aust Vet J 76, 317-321.
  • Swanepoel N et al (1998) Psychogenic alopecia in a cat - response to clomipramine. J S Afr Vet Assoc 69 (1), 22.

Other sources of information

  • Based on BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK. 
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, USA. pp 148-150.
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