ISSN 2398-2950      

Clindamycin

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Synonym(s): Antirobe


Introduction

Name

  • Clindamycin.

Class of drug

  • Lincosamide antibiotic.
  • Bacteriostatic or bactericidal, depending on concentration.

Description

Chemical name

  • (2S-trans)-methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside.

Molecular formula

  • C18H22ClN2O5S.

Physical properties

  • Multi-colored capsules.

Storage requirements

  • <25°C.
  • Do not refrigerate.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Cross-resistance

  • Complete cross-resistance between lincomycin Lincomycin and clindamycin.
  • Partial cross-resistance with erythromycin Erythromycin.

Non-depolarizing muscle relaxants (eg tubocurarine)

  • May be increased by clindamycin.

Neostigmine and pyridostigmine

Erythromycin

  • See also erythromycin   Erythromycin  .
  • Antagonize each other's effects in vitro; clinical significance unknown.

Clindamycin can cause neuromuscular blockade; avoid use with aminoglycosides or anesthetic neuromuscular blockade.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.
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