ISSN 2398-2950      

Cisapride

ffelis
Contributor(s):

Vetstream Ltd

Synonym(s): Prepulsid


Introduction

Name

  • Cisapride.

Class of drug

  • Prokinetic agent.

Description

Chemical name

  • cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidninyl]-2-methoxybenzamide;cis-4-amino-5-chloro-N-[1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide.

Molecular formula

  • C23H29ClFN3O4.

Storage requirements

  • Store at room temperature.
  • Keep out of light and keep dry.

Uses

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Indications

  • Management of:
    • Esphageal reflux.
    • Gastric stasis.
    • Megacolon Megacolon.
    Cisapride has been withdrawn for use in humans in both the UK (July 2000) and USA. This decision follows reports of rare, but serious, ventricular arrhythmias (some fatal) suspected to be caused by the drug.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Opioid analgesics and antimuscarinics (eg atropineAtropine) may antagonize cisapride's effects.
  • Fatal arrhythmia may be seen in conjunction with:
    • Erythromycin, clarythromycin, troleandomycin.
    • Itraconazole, ketoconazole, fluconazole and micoconazole.
  • Increases bioavailability of ciclosporin.
  • Increases absorption of aspirin, acetaminophen, diazepam, ethanol.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • LeGrange S N, Boothe D M & Herndon S et al (1997) Pharmacokinetics and suggested oral dosing regime of cisapride - a study in healthy cats. JAAHA 33, 517-523.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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