ISSN 2398-2950      

Chlorambucil

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Introduction

Name

  • Chlorambucil.

Class of drug

  • Antineoplastic cytotoxic immunosuppressive alkylating agent.

Description

Chemical name

  • 4-[bis(2-chloroethyl)amino]benzenebutanoic acid.
  • 4-[p-[bis(2-chloroethyl)amino]phenyl]butryic acid.

Molecular formula

  • C14H19Cl2NO2.

Physical properties

  • 2 mg tablets.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Phenobarbital   Phenobarbital  - increases cytotoxic effects of chlorambucil.
  • Prednisolone   Prednisolone  - synergistic effect in management of lymphoid neoplasia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
  • Plumb D (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press.
  • Fraizier D L & Hahn K A (1995) Commonly Used Drugs. In: Cancer Chemotherapy A Veterinary Handbook. Eds: Hahn K A & Richardson R C. Williams & Wilkins, USA. pp 90.
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