ISSN 2398-2950      

Cefotaxime

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Contributor(s):

Vetstream Ltd


Introduction

Name

  • Cefotaxime.

Class of drug

  • Third generation cephalosporin antibiotic.

Uses

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Indications

  • Many Gram-negative infections (notPseudomonasspp).
  • Use reserved for patients suffering from acute sepsis or serious infections where cultures are pending and the animal is not a good candidate for intensive aminoglycoside therapy (pre-existing renal dysfunction).
  • Cephalosporins are particularly useful for the treatment of susceptible renal infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • The bactericidal activity of cephalosporins may be affected by the concomitant use of bacteriostatic agents (eg tetracycline   Tetracycline  , erythromycin   Erythromycin  ).
  • There may be an increased risk of nephrotoxicity if cephalosporins are used with amphotericin   Amphotericin B  or loop diuretics; monitor renal function.
  • Probenecid reduces the excretion of cephalosporins.

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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