Felis ISSN 2398-2950

Carprofen

Contributor(s): Vetstream Ltd

Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Analgesic activity enhanced if used pre-emptively.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.

Nephrotoxic agents

  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Further Reading

Publications

Refereed Papers

  • Al-Gizawiy M M & Rudé P E (2004) Comparison of preoperative carprofen and postoperative butorphanol as postsurgical analgesics in cats undergoing ovariohysterectomy.Vet Anaesth Analg. 31(3), 164-174 DOI.
  • Tomlinson J & Blikslager A (2003) Role of non-steroidal anti-inflammatory drugs in gastrointestinal tract injury and repairJAVMA 222(7), 946-951 PubMed.
  • Halter F, Tarnawski AS, Schmassmann A & Peskar BM (2001) Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectivesGut 49(30), 443-453 PubMed.
  • Firth A M & Haldane S L (1999) Development of a scale to evaluate post operative pain in dogs. JAVMA 214(5), 651-659 PubMed.
  • Isaacs J P (1999) CarprofenComp Contin Educ Pract Vet 21(3) , 246-248.
  • Lascelles B D X, Cripps P J, Jones A & Waterman-Pearson A E (1998) Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 27(6), 568-582 PubMed.
  • Balmer T & Curwen A (1997) Analgesia in catsVet Rec 140, 435 PubMed.
  • Mizuno H, Sakamoto, Matsuda K et al(1997) Induction of cycooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology,112. 387-397 PubMed.
  • David A & Simon A (1999) Use of Rimadyl in cats.Vet Rec 145, 743 (Letter) PubMed/

Other sources of information

  • Pfizer, Inc. Five-year safety profile for Rimadyl (carprofen) (2002).
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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