ISSN 2398-2950      

Carboplatin

ffelis

Synonym(s): Paraplatin


Introduction

Name

  • Carboplatin.

Class of drug

  • Platinum compound antineoplastic agent.
  • Alkylating type agent.

Description

Chemical name

  • (SP-4-2)-Diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex.

Molecular formula

  • C6H12N2O4Pt.

Physical properties

  • White crystals.
  • Soluble in water.

Storage requirements

  • Room temperature and protected from light.
  • Reconstituted solutions at 1 mg/ml are stable for 24 hours at room temperature and 5 days in refrigerator.

Uses

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Indications

  • Used against various carcinomas and sarcomas.
  • Has been used in vaccine-associated sarcomas in cats   Feline injection-site associated sarcoma  .
  • Reported to increase the survival time when used as an adjunct to amputation in dogs with appendicular osteosarcoma. Seek specialist advice before use.

Administration

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Pharmacokinetics

Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rassnick K M et al (2001) Use of carboplatin for treatment of dogs with malignant melanoma- 27 cases (1989-2000). JAVMA 218 (9), 1444-1448.
  • Fox L E (2000) Carboplatin. JAAHA 36 (1), 13-4.
  • Hahn K A et al (1997) Hematologic and systemic toxicoses associated with carboplatin administration in cats. Am J Vet Res 58 (6), 677-679.

Other sources of information

  • Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook. 6th edn. Mosby, USA. pp 234-236.
  • Plumb D C (2002) Veterinary Drug Handbook. 4th edn. Iowa State Press, USA. pp 132-134.
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK. ISBN: 0 9052 1452 8.
  • Theon A (1997) Intratumoral Chemotherapy in Small Animals. In: Proceedings of the 15th Annual Veterinary Medical Forum American College of Veterinary Internal Medicine. pp 180-181.
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