Felis ISSN 2398-2950

Cabergoline

Contributor(s): David Godfrey, Vetstream Ltd

Introduction

Name

  • Cabergoline.

Class of drug

  • Dopamine receptor agonist.

Description

Chemical name

  • 1-6-Allilergolin-8beta-ylcarbonyl-1-3-dimethylaminepropyl-3-ethylurea.

Molecular formula

  • Non-hormonal ergoline derivative.

Uses

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Indications

Dog

  • Treatment of pseudopregnancy Pseudopregnancy.
  • Suppression of milk production.
  • Adjunct in treatment of eclampsia and mastitis Mastitis.
  • Inducing abortion.
  • Reducing mammary tissue size in prolactin-dependent tumors Mammary gland: neoplasia.
  • Induction of estrus in the bitch Failure to show estrus.
  • May be used in conjunction with F2a prostaglandin analogue (eg dinoprost Dinoprost trimethamine) to terminate unwanted pregnancy in the bitch. Pregnancy termination takes place by resorption of the fetuses.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Harvey M J A, Dale M J, Lindley & Waterston M M (1999) A study of the aetiology of pseudopregnancy in the bitch and the effect of cabergoline therapy. Vet. Rec 144, 433-436.
  • Onclin K, Silva L D M, Donnay I and Verstegen J P (1999) Luteotrophic action of prolactin in dogs and the effects of a dopamine antagonist, cabergoline. J Reproduction and Fert Supl 47, 403-409.
  • Jochle W & Jochle M (1993) Reproduction in a feral cat population and its control with a prolactin inhibitor, cabergoline. J Reprod Fertil Suppl. 47, 419-424.

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