ISSN 2398-2950      

Betamethasone

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Introduction

Name

  • Betamethasone.

Class of drug

  • Glucocorticoid.

Description

Chemical name

  • (11-beta,16-beta)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H29FO5.

Physical properties

  • Sterile, white aqueous suspension.
  • White tablets.
  • Slightly viscous, yellow oily suspension.

Storage requirements

  • <25°C.
  • Do not store in fridge or freezer.

Uses

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Indications

  • Anti-inflammatory - potency 8.75 times greater than prednisolone.
  • May have role in management of shock   Shock  .

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Anti-epileptic drugs (phenobarbital, phenytoin and primidone)

  • Metabolism of corticosteroids may be accelerated.

Insulin

  • Glucocorticoids may antagonize the effect of insulin.

Acetazolamide, amphotericin and potassium depleting diuretics (furosemide, thiazides)
Non-steroidal anti-inflammatory drugs

  • Increased risk of gastrointestinal ulceration if NSAIDs used concurrently.
  • Concurrent use of corticosteroids increases risk of hypokalemia.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ramsey I (2017) Small Animal Formulary. 9th edn. 
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