ISSN 2398-2950      

Atenolol

ffelis
Contributor(s):

Mark Rishniw

Vetstream Ltd


Introduction

Name

  • Atenolol.

Class of drug

  • Beta-1 adrenoceptor antagonist(beta blocker).

Description

Chemical name

  • 4-[2'-hydroxy-3'-[(1-methylethyl)amino]propoxy]-benzeneacetamide.

Molecular weight

  • 266.

Physical properties

  • H2O soluble.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Sympathomimetics, eg epinephrine  Epinephrine , phenylpropanolamine  Phenylpropanolamine / diphenylpyraline , terbutaline  Terbutaline 
  • May have their beta-effects blocked by atenolol.
  • Thus, the unopposed alpha effects may result in severe hypertension and a decreased heart rate.

Anesthetic agents (those that depress myocardial activity), phenothiazines, antihypertensive drugs (eg hydralazine  Hydralazine , prazosin), diazepam  Diazepam , diuretics and other anti-arrhythmics

  • Hypotensive effect of atenolol enhanced.

Calcium channel blockers, eg diltiazem  Diltiazem , verapamil  Verapamil 

  • There is an increased risk of bradycardia, severe hypotension, heart failure and AV block if used concurrently with atenolol.

Digoxin  Digoxin 

  • Concurrent administration potentiates bradycardia.

Aluminum hydroxide

  • Oral preparations reduce atenolol absorption.

Cimetidine  Cimetidine 

  • May decrease the metabolism of atenolol, thereby increasing its blood levels.

Muscle relaxants, eg tubocurarine, suxamethonium  Suxamethonium 

  • Effects enhanced by atenolol.

Phenobarbitone  Phenobarbital , rifampin or phenytoin  Phenytoin 

  • Hepatic enzyme induction by these drugs may increase the rate of metabolism of atenolol.

Insulin  Insulin 

  • May prolong the hypoglycemic effects of insulin therapy.

Theophylline  Theophylline 

  • The bronchodilatory effects may be blocked by atenolol.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Quinones M et al (1996) Pharmacokinetics of atenolol in clinically normal cats. AJVR 57 (7), 1050-1053.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. BSAVA, UK.
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