ISSN 2398-2950      

Amlodipine

ffelis
Contributor(s):

Esther Bijsmans


Introduction

Name

  • Amlodipine besylate.

Class of drug

  • Third generation dihydropyridine .
  • Calcium-channel blocker.

Description

Chemical name

  • (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate.

Molecular formula

  • C20H25ClN2O5

Molecular weight

  • 408.879

Storage requirements

  • Amodip 1.25 mg chewable tablets for cats:
    • Do not store above 30°C.
    • Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
    • Shelf life of halved tablets: 24 hours.
    • Any unused half tablets should be returned to the blister pack.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with diagnostic tests

  • Successful antihypertensive treatment with amlodipine is associated with a decrease in urine protein:creatinine ratios. Ventricular hypertrophy (diagnosed by echocardiography) may resolve after the initiation of amlodipine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Huhtinen M, Derré G, Renoldi H J et al (2015) Randomized placebo-controlled clinical trial of a chewable formulation of amlodipine for the treatment of hypertension in client-owned cats.J Vet Intern Med 29 (3), 786-793 PubMed.
  • Helms S R (2007) Treatment of Feline Hypertension With Transdermal Amlodipine: A Pilot Study. JAAHA 43 (3), 149-156 PubMed.
  • Jepson R E, Elliott J, Brodbeld D, Syme H M (2007) Effect of control of systolic blood pressure on survival in cats with systemic hypertension. J Vet Intern Med 21, 402-409 PubMed.
  • Snyder P S, Sadek D, Jones G L (2001) Effect of amlodipine on echocardiographic variables in cats with systemic hypertension. J Vet Intern Med 15 (1), 52-56 PubMed.
  • Elliott J, Barber PJ, Syme H M, Rawlings J M & Markwell P J (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 casesJ Small Anim Pract 42 (3), 122-129 PubMed.
  • Snyder P S (1998) Amlodipine: a randomized, blinded, clinical trial in 9 cats with systemic hypertension. J Vet Intern Med 12,157-162 PubMed.

Other sources of information

  • Bijsmans E S, Jepson R E, Syme H M, Elliott J, Pelligand L (2015) Measurement of plasma amlodipine concentration using LC/MS/MS at the point of blood pressure control in hypertensive cats (abstract). J Vet Intern Med 29 (4), 1224 (ACVIM Forum Abstract).
  • Small Animal Formulary. Tennant, Bryn (2014) 8th edn. BSAVA, UK.
  • Bijsmans E S, Jepson R E, Syme H M & Elliott J (2014) The efficacy of amlodipine besylate to control hypertension in cats with CKD (abstract). BSAVA Congress Proceedings.
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