Felis ISSN 2398-2950

Alfaxalone (Alfaxan)

Synonym(s): Alfaxan-CD RTU (where CD=cyclodextrin; RTU=ready to use)

Contributor(s): Len Cullen, Polly Taylor, Jo Murrell

Introduction

Name

  • Alfaxalone (Alfaxan).

Class of drug

  • Steroid general anesthetic.

Description

Chemical name

  • 3-hydroxy-5-pregnane-11,20-dione.

Physical properties

  • Clear, colorless solution for injection presented in a multi-dose bottle.
  • pH of solution: 6.5 to 7.0.
  • Concentration: 10 mg/ml.

Storage requirements

  • Store below 30°C.
  • Protect from light.
  • Multi-dose vial available - use within 28 days of broaching the vial.

Uses

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Indications

  • Injectable anesthetic agent for dogs and cats.
  • Given alone as a single bolus dose or in incremental doses or by continuous rate infusion.
  • Given for anesthetic induction prior to tracheal intubation Endotracheal intubation and maintenance with inhalational anesthesia.
  • Given intramuscularly to induce a brief period of sedation (10-15 minutes).

Administration

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Granfone M C, Walker J M, Smith L J (2018) Evaluation of an intramuscular butorphanol and alfaxalone protocol for feline blood donation: a pilot study. J Feline Med Surg 20(8), 793-798 PubMed.
  • Tamura J, Ishizuka T, Fukui S, Oyama N, Kawase K, Itami T, Miyoshi K, Sano T, Pasloske K, Yamashita K (2015) Sedative effects of intramuscular alfaxalone administered to cats. J Vet Med Sci 77(8), 897-904 PubMed.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 
  • Technical Manual, Jurox Pty Ltd, Rutherford. NSW 2320, Australia.

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